17 Nov 2012 Point mutations that create hypomorphic alleles of the Nkx2.5 gene have been Mef2c knockout mice were generated from mice bearing a
We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene
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We found the binding of NKX2.5 specific to the non-susceptible T allele in the autoimmune diseases that predominantly afflict women of child-bearing age.
9 May 2013 A novel heterozygous mutation, I184M, located within the NKX2-5 .. A mutant form of the cardiac trascription factor TBX1 bearing a
6 Jul 2015 Our study reveals binding and activities of NKX2-5 mutations on WT .. 79% of NKX2-5 peaks, with half of these bearing over 2 and up to 12
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17 Feb 2016 A novel conditional mouse model for Nkx2-5 reveals transcriptional abnormalities observed in patients bearing NKX2-5 dysfunction and
body wall muscle and that nkx2.5 can rescue a ceh-22 mutant when expressed in . In a transgenic strain bearing the unc-54::nkx2.5 expression construct, we
22 Aug 2008 The cardiac specific homeobox gene nkx2.5, a member of the nk-2 .. The asterisks indicate the altered complexes bearing Nkx2.5 (free or
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Here we use human pluripotent stem cells bearing a cardiac lineage reporter to show NKX2-5-eGFP expression is activated in spheres by concerted FGF and
Expression of the Nkx2.5 mutant transgene in the wild type murine hearts did To gain an insight into cardiac functions in the mice bearing the K51R mutant,
This study establishes that a Pbx/Nkx2-5/p15 regulatory module is essential .. bearing mutations of critical YRD domain Tyrosines showed low Luc activity in
All embryos and mice were genotyped for Nkx2-5 and minK-lacZ gene dosage; all comparisons using the minK-lacZ marker were made between hearts bearing
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14 Jun 2010 The PA-specific Jarid2 mRNA expression observed at E9.5 stages is consistent with lacZ expression patterns reported in mice bearing a gene
to human Nkx2-5 HD mutations or reported functional variants10,13,14,21,22. Results were .. A mutant form of the cardiac TF TBX1 bearing a poly-alanine